Kinase II - 2 and Fyn
نویسندگان
چکیده
Background: Increased vascular smooth muscle cell motility results in neointimal formation. Results: CaMKII2 and Fyn physically interact and CaMKII2 activity regulates complex formation, Fyn activity, and motility. Conclusion: CaMKII2 and Fyn regulate VSM cell motility due to their physical and functional interaction. Significance: Coupling CaMKII2 and Fyn in VSM provides a defined mechanism for increases in intracellular calcium to activate tyrosine kinases required for cell motility.
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